CATH Domain 4uqfG01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.286	GTP Cyclohydrolase I; Chain A, domain 1
	1.10.286.10	GTP cyclohydrolase I, N-terminal domain

Domain Context

CATH Clusters

Superfamily	1.10.286.10
Functional Family	GTP cyclohydrolase 1

Enzyme Information

3.5.4.16

GTP cyclohydrolase I.

based on mapping to UniProt Q8Y5X1

GTP + H(2)O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3- trihydroxypropyl)-dihydropteridine triphosphate.

-!- The reaction involves hydrolysis of two C-N bonds and isomerization of the pentose unit; the recyclization may be non-enzymic. -!- Involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 and EC 4.2.3.12.

UniProtKB Entries (1)

Q8Y5X1

GCH1_LISMO

Listeria monocytogenes EGD-e

GTP cyclohydrolase 1

PDB Structure

PDB	4UQF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of GTP cyclohydrolase I from Listeria monocytogenes, a potential anti-infective drug target. Schussler, S., Haase, I., Perbandt, M., Illarionov, B., Siemens, A., Richter, K., Bacher, A., Fischer, M., Grawert, T. Acta Crystallogr.,Sect.F

Network disruptions