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1 keywords

CATH Domain 4rhxB00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.2020  

Domain Context

CATH Clusters

Superfamily 3.40.50.2020
Functional Family Hypoxanthine phosphoribosyltransferase

Enzyme Information

2.4.2.8
Hypoxanthine phosphoribosyltransferase.
based on mapping to UniProt P9WHQ9
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- Guanine and 6-mercaptopurine can replace hypoxanthine.

UniProtKB Entries (1)

P9WHQ9
HPRT_MYCTU
Mycobacterium tuberculosis H37Rv
Hypoxanthine-guanine phosphoribosyltransferase

PDB Structure

PDB 4RHX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.
Eng, W.S., Hockova, D., Spacek, P., Janeba, Z., West, N.P., Woods, K., Naesens, L.M., Keough, D.T., Guddat, L.W.
J.Med.Chem.
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