CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1240 | Phosphoglycerate mutase-like |
Domain Context
CATH Clusters
| Superfamily | Phosphoglycerate mutase-like |
| Functional Family | Glucosyl-3-phosphoglycerate phosphatase |
Enzyme Information
| 3.1.3.85 |
Glucosyl-3-phosphoglycerate phosphatase.
based on mapping to UniProt P9WIC6
2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate + H(2)O = 2-O-(alpha- D-glucopyranosyl)-D-glycerate + phosphate.
-!- The enzyme is involved in biosynthesis of 2-O-(alpha-D- glucopyranosyl)-D-glycerate via the two-step pathway in which EC 2.4.1.266 catalyzes the conversion of GDP-glucose and 3-phospho-D- glycerate into 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate, which is then converted to 2-O-(alpha-D-glucopyranosyl)-D-glycerate by glucosyl-3-phosphoglycerate phosphatase. -!- In vivo the enzyme catalyzes the dephosphorylation of 2-O-(alpha-D- mannopyranosyl)-3-phospho-D-glycerate with lower efficiency. -!- Divalent metal ions (Mg(2+), Mn(2+) or Co(2+)) stimulate activity.
|
| 3.1.3.70 |
Mannosyl-3-phosphoglycerate phosphatase.
based on mapping to UniProt P9WIC6
2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H(2)O = 2-O-(alpha-D- mannosyl)-D-glycerate + phosphate.
-!- The enzyme from Pyrococcus horikoshii is specific for alpha-D- mannosyl-3-phosphoglycerate and forms part of the pathway for the synthesis of mannosylglycerate.
|
UniProtKB Entries (1)
| P9WIC6 |
GPGP_MYCTO
Mycobacterium tuberculosis CDC1551
Glucosyl-3-phosphoglycerate phosphatase
|
PDB Structure
| PDB | 4PZA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Mechanism of dephosphorylation of glucosyl-3-phosphoglycerate by a histidine phosphatase
J.Biol.Chem.
|
