CATH Domain 4o26B00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.132	Topoisomerase I; Chain A, domain 4
	1.10.132.70

Domain Context

CATH Clusters

Superfamily	1.10.132.70
Functional Family	Telomerase reverse transcriptase

Enzyme Information

2.7.7.49

RNA-directed DNA polymerase.

based on mapping to UniProt Q1PS67

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

-!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.

UniProtKB Entries (1)

Q1PS67

TERT_ORYLA

Oryzias latipes

Telomerase reverse transcriptase

PDB Structure

PDB	4O26
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis for protein-RNA recognition in telomerase. Huang, J., Brown, A.F., Wu, J., Xue, J., Bley, C.J., Rand, D.P., Wu, L., Zhang, R., Chen, J.J., Lei, M. Nat.Struct.Mol.Biol.