CATH Domain 4mr6A00

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.920	Histone Acetyltransferase; Chain A
	1.20.920.10	Bromodomain-like

Domain Context

CATH Clusters

Superfamily	Bromodomain-like
Functional Family	Bromodomain-containing protein 2

Enzyme Information

UniProtKB Entries (1)

BRD2_HUMAN

Homo sapiens

Bromodomain-containing protein 2

PDB Structure

PDB	4MR6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. Picaud, S., Wells, C., Felletar, I., Brotherton, D., Martin, S., Savitsky, P., Diez-Dacal, B., Philpott, M., Bountra, C., Lingard, H., Fedorov, O., Muller, S., Brennan, P.E., Knapp, S., Filippakopoulos, P. Proc.Natl.Acad.Sci.USA