CATH Domain 4k22A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.50	3-Layer(bba) Sandwich
	3.50.50	FAD/NAD(P)-binding domain
	3.50.50.60	FAD/NAD(P)-binding domain

Domain Context

CATH Clusters

Superfamily	FAD/NAD(P)-binding domain
Functional Family

Enzyme Information

1.14.13.240

2-polyprenylphenol 6-hydroxylase.

based on mapping to UniProt P25535

2-(all-trans-polyprenyl)phenol + NADPH + O(2) = 3-(all-trans- polyprenyl)benzene-1,2-diol + NADP(+) + H(2)O.

-!- The enzyme from the bacterium Escherichia coli (UbiI) catalyzes the first hydroxylation during the aerobic biosynthesis of ubiquinone. -!- The enzyme from the bacterium Neisseria meningitidis (UbiM) can also catalyze the two additional hydroxylations that occur in the pathway (cf. EC 1.14.99.60).

UniProtKB Entries (1)

P25535

UBII_ECOLI

Escherichia coli K-12

2-octaprenylphenol hydroxylase

PDB Structure

PDB	4K22
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	ubiI, a New Gene in Escherichia coli Coenzyme Q Biosynthesis, Is Involved in Aerobic C5-hydroxylation. Chehade, M.H., Loiseau, L., Lombard, M., Pecqueur, L., Ismail, A., Smadja, M., Golinelli-Pimpaneau, B., Mellot-Draznieks, C., Hamelin, O., Aussel, L., Kieffer-Jaquinod, S., Labessan, N., Barras, F., Fontecave, M., Pierrel, F. J.Biol.Chem.

Network disruptions