CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family | Formate--tetrahydrofolate ligase |
Enzyme Information
| 6.3.4.3 |
Formate--tetrahydrofolate ligase.
based on mapping to UniProt Q2RM91
ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
-!- In eukaryotes occurs as a trifunctional enzyme also having EC 1.5.1.5 and EC 3.5.4.9 activity.
|
UniProtKB Entries (1)
| Q2RM91 |
FTHS_MOOTA
Moorella thermoacetica ATCC 39073
Formate--tetrahydrofolate ligase
|
PDB Structure
| PDB | 4JJZ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Mechanism of N10-formyltetrahydrofolate synthetase derived from complexes with intermediates and inhibitors.
Protein Sci.
|
