CATH Domain 4j2tA03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1000	HAD superfamily/HAD-like

Domain Context

CATH Clusters

Superfamily	HAD superfamily/HAD-like
Functional Family	Calcium-transporting ATPase 1

Enzyme Information

7.2.2.10

P-type Ca(2+) transporter.

based on mapping to UniProt P04191

ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).

-!- A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. -!- This enzyme family comprises three types of Ca(2+)-transporting enzymes that are found in the plasma membrane, the sarcoplasmic reticulum, in yeast, and in some bacteria. -!- The enzymes from plasma membrane and from yeast have been shown to transport one ion per ATP hydrolyzed whereas those from the sarcoplasmic reticulum transport two ions per ATP hydrolyzed. -!- In muscle cells Ca(2+) is transported from the cytosol into the sarcoplasmic reticulum. -!- Formerly EC 3.6.1.38 and EC 3.6.3.8.

UniProtKB Entries (1)

P04191

AT2A1_RABIT

Oryctolagus cuniculus

Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

PDB Structure

PDB	4J2T
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase. Paulsen, E.S., Villadsen, J., Tenori, E., Liu, H., Bonde, D.F., Lie, M.A., Bublitz, M., Olesen, C., Autzen, H.E., Dach, I., Sehgal, P., Nissen, P., Moller, J.V., Schiott, B., Christensen, S.B. J.Med.Chem.