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1 keywords

CATH Domain 4j0eA02

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.1040 N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Homologous Superfamily 1.10.1040.10 N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2

Domain Context

CATH Clusters

Superfamily N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family

Enzyme Information

1.1.1.35
3-hydroxyacyl-CoA dehydrogenase.
based on mapping to UniProt P34439
(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
-!- Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate. -!- Some enzymes act, more slowly, with NADP(+). -!- Broad specificity to acyl chain-length (cf. EC 1.1.1.211).

UniProtKB Entries (1)

P34439
HCDH1_CAEEL
Caenorhabditis elegans
Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1

PDB Structure

PDB 4J0E
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Purification, crystallization and preliminary crystallographic analysis of 3-hydroxyacyl-CoA dehydrogenase from Caenorhabditis elegans.
Xu, Y., Sun, F.
Acta Crystallogr.,Sect.F
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