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1 keywords

CATH Domain 4hwrB02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.800 Anticodon-binding domain

Domain Context

CATH Clusters

Superfamily Anticodon-binding domain
Functional Family Threonine--tRNA ligase

Enzyme Information

6.1.1.3
Threonine--tRNA ligase.
based on mapping to UniProt P0A8M3
ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

UniProtKB Entries (1)

P0A8M3
SYT_ECOLI
Escherichia coli K-12
Threonine--tRNA ligase

PDB Structure

PDB 4HWR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design.
Teng, M., Hilgers, M.T., Cunningham, M.L., Borchardt, A., Locke, J.B., Abraham, S., Haley, G., Kwan, B.P., Hall, C., Hough, G.W., Shaw, K.J., Finn, J.
J.Med.Chem.
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