CATH Domain 4h4fA01

×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Chymotrypsin-like elastase family member 1

Enzyme Information

3.4.21.2

Chymotrypsin C.

based on mapping to UniProt Q99895

Preferential cleavage: Leu-|-Xaa, Tyr-|-Xaa, Phe-|-Xaa, Met-|-Xaa, Trp-|-Xaa, Gln-|-Xaa, Asn-|-Xaa.

-!- Reacts more readily with Tos-Leu-CH(2)Cl than Tos-Phe-CH(2)Cl, in contrast to chymotrypsin. -!- Belongs to peptidase family S1.

UniProtKB Entries (2)

P01051	ICIC_HIRME Hirudo medicinalis Eglin C
Q99895	CTRC_HUMAN Homo sapiens Chymotrypsin-C

PDB Structure

PDB	4H4F
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation. Batra, J., Szabo, A., Caulfield, T.R., Soares, A.S., Sahin-Toth, M., Radisky, E.S. J.Biol.Chem.