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1 keywords

CATH Domain 4gwnA03

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.60 Sandwich
Topology 2.60.210 Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
Homologous Superfamily 2.60.210.10 Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A

Domain Context

CATH Clusters

Superfamily Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
Functional Family Meprin A subunit

Enzyme Information

3.4.24.63
Meprin B.
based on mapping to UniProt Q16820
Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of 5-His-|-Leu-6, 6-Leu-|-Cys-7, 14-Ala-|-Leu-15 and 19-Cys-|-Gly-20 bonds in insulin B chain.
-!- Inhibited by EDTA and 1,10-phenanthroline, but not by phosphoramidon, captopril or thiorphan. -!- Belongs to peptidase family M12A.

UniProtKB Entries (1)

Q16820
MEP1B_HUMAN
Homo sapiens
Meprin A subunit beta

PDB Structure

PDB 4GWN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for the sheddase function of human meprin beta metalloproteinase at the plasma membrane
Arolas, J.L., Broder, C., Jefferson, T., Guevara, T., Sterchi, E.E., Bode, W., Stocker, W., Becker-Pauly, C., Gomis-Ruth, F.X.
Proc.Natl.Acad.Sci.USA
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