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1 keywords

CATH Domain 4fgcC00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.1130 GTP Cyclohydrolase I, domain 2
Homologous Superfamily 3.30.1130.10 GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

Domain Context

CATH Clusters

Superfamily 3.30.1130.10
Functional Family

Enzyme Information

1.7.1.13
PreQ(1) synthase.
based on mapping to UniProt O31678
7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7-carbaguanine + 2 NADPH.
-!- The reaction occurs in the reverse direction. -!- This enzyme catalyzes one of the early steps in the synthesis of queosine (Q-tRNA), and is followed by the action of EC 2.4.2.29. -!- Queosine is found in the wobble position of tRNA(GUN) in eukaryotes and bacteria and is thought to be involved in translational modulation.

UniProtKB Entries (1)

O31678
QUEF_BACSU
Bacillus subtilis subsp. subtilis str. 168
NADPH-dependent 7-cyano-7-deazaguanine reductase

PDB Structure

PDB 4FGC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis of biological nitrile reduction.
Chikwana, V.M., Stec, B., Lee, B.W., de Crecy-Lagard, V., Iwata-Reuyl, D., Swairjo, M.A.
J.Biol.Chem.
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