CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.850 | Hydroxylamine Oxidoreductase; Chain A, domain 2 |
|
1.20.850.10 | Hydroxylamine Oxidoreductase; Chain A, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Hydroxylamine Oxidoreductase; Chain A, domain 2 |
| Functional Family | Hydroxylamine oxidoreductase |
Enzyme Information
| 1.7.2.6 |
Hydroxylamine dehydrogenase.
based on mapping to UniProt Q50925
(1) Hydroxylamine + H(2)O + 4 ferricytochrome c = nitrite + 4 ferrocytochrome c + 5 H(+). (2) Hydroxylamine + 3 ferricytochrome c = nitric oxide + 3 ferrocytochrome c + 3 H(+).
-!- The enzymes from the nitrifying bacterium Nitrosomonas europaea and the methylotrophic bacterium Methylococcus capsulatus are hemoproteins with seven c-type hemes and one specialized P460-type heme per subunit. -!- The enzyme converts hydroxylamine to nitrite via an enzyme-bound nitroxyl intermediate. -!- While nitrite is the main product, the enzyme from Nitrosomonas europaea can produce nitric oxide as well. -!- Formerly EC 1.7.3.4.
|
UniProtKB Entries (1)
| Q50925 |
HAO_NITEU
Nitrosomonas europaea ATCC 19718
Hydroxylamine oxidoreductase
|
PDB Structure
| PDB | 4FAS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural studies of hydroxylamine oxidoreductase reveal a unique heme cofactor and a previously unidentified interaction partner.
Biochemistry
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