CATH Domain 4e90A00

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1300	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
	1.10.1300.10	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Domain Context

CATH Clusters

Superfamily	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family	Phosphodiesterase 9A

Enzyme Information

3.1.4.35

3',5'-cyclic-GMP phosphodiesterase.

based on mapping to UniProt O76083

Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

UniProtKB Entries (1)

PDE9A_HUMAN

Homo sapiens

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

PDB Structure

PDB	4E90
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors. Claffey, M.M., Helal, C.J., Verhoest, P.R., Kang, Z., Fors, K.S., Jung, S., Zhong, J., Bundesmann, M.W., Hou, X., Lui, S., Kleiman, R.J., Vanase-Frawley, M., Schmidt, A.W., Menniti, F., Schmidt, C.J., Hoffman, W.E., Hajos, M., McDowell, L., O'Connor, R.E., Macdougall-Murphy, M., Fonseca, K.R., Becker, S.L., Nelson, F.R., Liras, S. J.Med.Chem.