CATH Domain 4dg4D02

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Anionic trypsin

Enzyme Information

3.4.21.4

Trypsin.

based on mapping to UniProt P35030

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

-!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.4.

UniProtKB Entries (2)

P35030	TRY3_HUMAN Homo sapiens Trypsin-3
P00974	BPT1_BOVIN Bos taurus Pancreatic trypsin inhibitor

PDB Structure

PDB	4DG4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors. Salameh, M.A., Soares, A.S., Alloy, A., Radisky, E.S. Protein Sci.