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1 keywords

CATH Domain 4d91A02

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.390 Neutral Protease; domain 2
Homologous Superfamily 1.10.390.10 Neutral Protease Domain 2

Domain Context

CATH Clusters

Superfamily Neutral Protease Domain 2
Functional Family Thermolysin

Enzyme Information

3.4.24.27
Thermolysin.
based on mapping to UniProt P00800
Preferential cleavage: Xaa-|-Leu > Xaa-|-Phe.
-!- A thermostable extracellular metalloendopeptidase containing four calcium ions. -!- Enzymes that may be species variants of thermolysin are reported from Micrococcus caseolyticus and Aspergillus oryzae. -!- Closely related but distinct enzymes are aeromonolysin, pseudolysin, bacillolysin, aureolysin and mycolysin. -!- Belongs to peptidase family M4. -!- Formerly EC 3.4.24.4.

UniProtKB Entries (1)

P00800
THER_BACTH
Bacillus thermoproteolyticus
Thermolysin

PDB Structure

PDB 4D91
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Thermolysin Inhibition
Biela, A., Nasief, N., Heine, A., Hangauer, D., Klebe, G.
To be Published
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