CATH Domain 4ca9E00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.340	Nucleoplasmin core domain

Domain Context

CATH Clusters

Superfamily	Nucleoplasmin core domain
Functional Family	39 kDa FK506-binding nuclear protein

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt P54397

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P54397

FKB39_DROME

Drosophila melanogaster

39 kDa FK506-binding nuclear protein

PDB Structure

PDB	4CA9
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	The Pentameric Nucleoplasmin Fold is Present in Drosophila Fkbp39 and a Large Number of Chromatin-Related Proteins. Edlich-Muth, C., Artero, J., Callow, P., Przewloka, M.R., Watson, A.A., Zhang, W., Glover, D.M., Debski, J., Dadlez, M., Round, A.R., Trevor Forsyth, V., Laue, E.D. J.Mol.Biol.