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1 keywords

CATH Domain 4bv2B02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.1600 SIR2/SIRT2 'Small Domain'
Homologous Superfamily 3.30.1600.10 SIR2/SIRT2 'Small Domain'

Domain Context

CATH Clusters

Superfamily SIR2/SIRT2 'Small Domain'
Functional Family Nad-dependent deacetylase 1 putative

Enzyme Information

3.5.1.-
In linear amides.
based on mapping to UniProt Q9WYW0

UniProtKB Entries (2)

P04637
P53_HUMAN
Homo sapiens
Cellular tumor antigen p53
Q9WYW0
NPD_THEMA
Thermotoga maritima MSB8
NAD-dependent protein deacetylase

PDB Structure

PDB 4BV2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Ex-527 Inhibits Sirtuins by Exploiting Their Unique Nad+-Dependent Deacetylation Mechanism
Gertz, M., Fischer, F., Nguyen, G.T.T., Lakshminarasimhan, M., Schutkowski, M., Weyand, M., Steegborn, C.
Proc.Natl.Acad.Sci.USA
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