CATH Domain 4bbmB01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	cyclin-dependent kinase-like 1 isoform X1

Enzyme Information

2.7.11.22

Cyclin-dependent kinase.

based on mapping to UniProt Q92772

ATP + a protein = ADP + a phosphoprotein.

-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q92772

CDKL2_HUMAN

Homo sapiens

Cyclin-dependent kinase-like 2

PDB Structure

PDB	4BBM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of the Human Cdkl2 Kinase Domain with Bound Tcs 2312 Canning, P., Elkins, J.M., Cooper, C.D.O., Mahajan, P., Daga, N., Berridge, G., Burgess-Brown, N., Muniz, J.R.C., Krojer, T., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Bullock, A. To be Published

Network disruptions