CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.2130 | VC0802-like |
|
3.30.2130.30 |
Domain Context
CATH Clusters
| Superfamily | 3.30.2130.30 |
| Functional Family | Ribosomal RNA large subunit methyltransferase K/L |
Enzyme Information
| 2.1.1.173 |
23S rRNA (guanine(2445)-N(2))-methyltransferase.
based on mapping to UniProt P75864
S-adenosyl-L-methionine + guanine(2445) in 23S rRNA = S-adenosyl-L- homocysteine + N(2)-methylguanine(2445) in 23S rRNA.
-!- The enzyme methylates 23S rRNA in vitro, assembled 50S subunits are not a substrate. -!- The enzyme specifically methylates guanine(2445) at N(2) in 23S rRNA. -!- Formerly EC 2.1.1.52.
|
| 2.1.1.264 |
23S rRNA (guanine(2069)-N(7))-methyltransferase.
based on mapping to UniProt P75864
S-adenosyl-L-methionine + guanine(2069) in 23S rRNA = S-adenosyl-L- homocysteine + N(7)-methylguanine(2069) in 23S rRNA.
-!- The enzyme specifically methylates guanine(2069) at position N7 in 23S rRNA. -!- In gamma-proteobacteria the enzyme also catalyzes EC 2.1.1.173, while in beta-proteobacteria the activities are carried out by separate proteins. -!- The enzyme from the gamma-proteobacterium Escherichia coli has RNA unwinding activity as well.
|
UniProtKB Entries (1)
| P75864 |
RLMKL_ECOLI
Escherichia coli K-12
Ribosomal RNA large subunit methyltransferase K/L
|
PDB Structure
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| Organism | |
| Primary Citation |
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