CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.120 | 6 Propeller |
|
2.120.10 | Neuraminidase |
|
2.120.10.10 |
Domain Context
CATH Clusters
| Superfamily | 2.120.10.10 |
| Functional Family | Hemagglutinin-neuraminidase |
Enzyme Information
| 3.2.1.18 |
Exo-alpha-sialidase.
based on mapping to UniProt P12554
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.
|
UniProtKB Entries (1)
| P12554 |
HN_NDVA
Newcastle disease virus (STRAIN AUSTRALIA-VICTORIA/32)
Hemagglutinin-neuraminidase
|
PDB Structure
| PDB | 3T1E |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk.
Proc.Natl.Acad.Sci.USA
|
