CATH Domain 3ozgD00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.2020

Domain Context

CATH Clusters

Superfamily	3.40.50.2020
Functional Family	Hypoxanthine phosphoribosyltransferase

Enzyme Information

2.4.2.8	Hypoxanthine phosphoribosyltransferase. based on mapping to UniProt P20035 IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate. -!- Guanine and 6-mercaptopurine can replace hypoxanthine.
2.4.2.22	Xanthine phosphoribosyltransferase. based on mapping to UniProt P20035 XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.

UniProtKB Entries (1)

HGXR_PLAFG

Plasmodium falciparum FCR-3/Gambia

Hypoxanthine-guanine-xanthine phosphoribosyltransferase

PDB Structure

PDB	3OZG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Acyclic Immucillin Phosphonates: Second-Generation Inhibitors of Plasmodium falciparum Hypoxanthine- Guanine-Xanthine Phosphoribosyltransferase. Hazleton, K.Z., Ho, M.C., Cassera, M.B., Clinch, K., Crump, D.R., Rosario, I., Merino, E.F., Almo, S.C., Tyler, P.C., Schramm, V.L. Chem.Biol.