CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.340 | Endonuclease III; domain 1 |
|
1.10.340.70 |
Domain Context
CATH Clusters
| Superfamily | 1.10.340.70 |
| Functional Family | Pro-Pol polyprotein |
Enzyme Information
| 3.1.-.- |
Acting on ester bonds.
based on mapping to UniProt P14350
|
| 3.4.23.- |
Aspartic endopeptidases.
based on mapping to UniProt P14350
|
| 2.7.7.49 |
RNA-directed DNA polymerase.
based on mapping to UniProt P14350
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
|
| 3.1.26.4 |
Ribonuclease H.
based on mapping to UniProt P14350
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- Acts on RNA-DNA hybrids.
|
| 2.7.7.7 |
DNA-directed DNA polymerase.
based on mapping to UniProt P14350
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
|
| 2.7.7.- |
Nucleotidyltransferases.
based on mapping to UniProt P14350
|
UniProtKB Entries (1)
| P14350 |
POL_FOAMV
Human spumaretrovirus
Pro-Pol polyprotein
|
PDB Structure
| PDB | 3OYG |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.
Proc.Natl.Acad.Sci.USA
|
