CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.120 | 6 Propeller |
|
2.120.10 | Neuraminidase |
|
2.120.10.90 | DNA gyrase/topoisomerase IV, subunit A, C-terminal |
Domain Context
CATH Clusters
| Superfamily | DNA gyrase/topoisomerase IV, subunit A, C-terminal |
| Functional Family | Type 2 topoisomerase subunit A |
Enzyme Information
| 5.6.2.3 |
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt O67108
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.
|
UniProtKB Entries (1)
| O67108 |
TOP4A_AQUAE
Aquifex aeolicus VF5
Type 2 topoisomerase subunit A
|
PDB Structure
| PDB | 3NO0 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A naturally chimeric type IIA topoisomerase in Aquifex aeolicus highlights an evolutionary path for the emergence of functional paralogs.
Proc.Natl.Acad.Sci.USA
|
