CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | Putative 2-dehydro-3-deoxy-D-gluconate aldolase YagE |
Enzyme Information
| 4.1.2.28 |
2-dehydro-3-deoxy-D-pentonate aldolase.
based on mapping to UniProt P75682
2-dehydro-3-deoxy-D-pentonate = pyruvate + glycolaldehyde.
|
| 4.1.2.51 |
2-dehydro-3-deoxy-D-gluconate aldolase.
based on mapping to UniProt P75682
2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde.
-!- The enzyme from the archaeon Picrophilus torridus is involved in D-glucose and D-galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. -!- In the direction of aldol synthesis the enzyme catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D- galactonate at a similar ratio. -!- It shows no activity with 2-dehydro-3-deoxy-D-gluconate 6-phosphate. -!- Cf. EC 4.1.2.14.
|
UniProtKB Entries (1)
| P75682 |
YAGE_ECOLI
Escherichia coli K-12
Putative 2-dehydro-3-deoxy-D-gluconate aldolase YagE
|
PDB Structure
| PDB | 3NEV |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Identification of biochemical and putative biological role of a xenolog from Escherichia coli using structural analysis.
Proteins
|
