CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.11840 | Diphthamide synthesis DPH1/DPH2 domain 1 |
Domain Context
CATH Clusters
| Superfamily | Diphthamide synthesis DPH1/DPH2 domain 1 |
| Functional Family | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 |
Enzyme Information
| 2.5.1.108 |
2-(3-amino-3-carboxypropyl)histidine synthase.
based on mapping to UniProt O58832
L-histidine-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-((3S)-3-amino-3-carboxypropyl)-L-histidine-[translation elongation factor 2] + S-methyl-5'-thioadenosine.
-!- Modifies a histidine residue of the translation elongation factor 2 (EF2) via a 3-amino-3-carboxypropyl radical. -!- The enzyme is present in archae and eukaryotes but not in eubacteria. -!- Part of diphthamide biosynthesis. -!- Formerly EC 2.5.1.n7.
|
UniProtKB Entries (1)
| O58832 |
DPH2_PYRHO
Pyrococcus horikoshii OT3
2-(3-amino-3-carboxypropyl)histidine synthase
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PDB Structure
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| Primary Citation |
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