CATH Domain 3hxfA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.25	Alpha Horseshoe
	1.25.40	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
	1.25.40.120	Protein prenylyltransferase

Domain Context

CATH Clusters

Superfamily	Protein prenylyltransferase
Functional Family	Geranylgeranyl transferase type-2 subunit alpha

Enzyme Information

2.5.1.60

Protein geranylgeranyltransferase type II.

based on mapping to UniProt Q08602

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl- protein + diphosphate.

-!- This enzyme, along with EC 2.5.1.58 and EC 2.5.1.59, constitutes the protein prenyltransferase family of enzymes. -!- Attaches geranylgeranyl groups to two C-terminal cysteines in Ras- related GTPases of a single family, the Rab family (Ypt/Sec4 in lower eukaryotes) that terminate in XXCC, XCXC and CCXX motifs. -!- Reaction is entirely dependent on the Rab substrate being bound to Rab escort protein (REP). -!- Post-translational modification with the geranylgeranyl moiety is essential for Rab GTPases to be able to control the processes of membrane docking and fusion.

UniProtKB Entries (1)

Q08603

PGTB2_RAT

Rattus norvegicus

Geranylgeranyl transferase type-2 subunit beta

PDB Structure

PDB	3HXF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors Tan, K.T., Guiu-Rozas, E., Bon, R.S., Guo, Z., Delon, C., Wetzel, S., Arndt, S., Alexandrov, K., Waldmann, H., Goody, R.S., Wu, Y.W., Blankenfeldt, W. J.Med.Chem.

Network disruptions