CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.1360 | Gyrase A; domain 2 |
|
3.30.1360.40 |
Domain Context
CATH Clusters
| Superfamily | 3.30.1360.40 |
| Functional Family | DNA gyrase subunit A |
Enzyme Information
| 5.6.2.3 |
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt P72525
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.
|
UniProtKB Entries (1)
| P72525 |
PARC_STRPN
Streptococcus pneumoniae TIGR4
DNA topoisomerase 4 subunit A
|
PDB Structure
| PDB | 3FOF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases
Nat.Struct.Mol.Biol.
|
