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1 keywords

CATH Domain 3eppB00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.150 Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family mRNA cap guanine-N7 methyltransferase

Enzyme Information

2.1.1.56
mRNA (guanine-N(7)-)-methyltransferase.
based on mapping to UniProt O43148
S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA.
-!- Adds an N(7)-methylguanine cap to mRNA. -!- The nucleoside next to the terminal guanosine may be either guanosine or adenosine.

UniProtKB Entries (1)

O43148
MCES_HUMAN
Homo sapiens
MRNA cap guanine-N7 methyltransferase

PDB Structure

PDB 3EPP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of mRNA cap guanine-N7 methyltransferase (RNMT) in complex with sinefungin.
Zeng, H., Amaya, M.F., Loppnau, P., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Botchkarev, A., Min, J., Plotnikov, A.N., Wu, H.
To be Published
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