CATH Domain 3e28E00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1050	Beta-carbonic Anhydrase; Chain A
	3.40.1050.10	Carbonic anhydrase

Domain Context

CATH Clusters

Superfamily	Carbonic anhydrase
Functional Family	Carbonic anhydrase

Enzyme Information

4.2.1.1

Carbonic anhydrase.

based on mapping to UniProt P45148

H(2)CO(3) = CO(2) + H(2)O.

-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

P45148

CAN_HAEIN

Haemophilus influenzae Rd KW20

Carbonic anhydrase 2

PDB Structure

PDB	3E28
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Allosteric site variants of Haemophilus influenzae beta-carbonic anhydrase. Rowlett, R.S., Tu, C., Lee, J., Herman, A.G., Chapnick, D.A., Shah, S.H., Gareiss, P.C. Biochemistry

Network disruptions