CATH Domain 3bbfE00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.141	Nucleoside diphosphate kinase-like domain

Domain Context

CATH Clusters

Superfamily	Nucleoside diphosphate kinase-like domain
Functional Family	Nucleoside diphosphate kinase B

Enzyme Information

2.7.4.6	Nucleoside-diphosphate kinase. based on mapping to UniProt P22392 ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. -!- Many nucleoside diphosphates can act as acceptors. -!- Many ribo- and deoxyribonucleoside triphosphates can act as donors.
2.7.13.3	Histidine kinase. based on mapping to UniProt P22392 ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. -!- This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine). -!- A number of histones can act as acceptor.

UniProtKB Entries (1)

NDKB_HUMAN

Homo sapiens

Nucleoside diphosphate kinase B

PDB Structure

PDB	3BBF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1. Dexheimer, T.S., Carey, S.S., Zuohe, S., Gokhale, V.M., Hu, X., Murata, L.B., Maes, E.M., Weichsel, A., Sun, D., Meuillet, E.J., Montfort, W.R., Hurley, L.H. Mol.Cancer Ther.