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1 keywords

CATH Domain 3a6uA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.79 Nucleoside Triphosphate Pyrophosphohydrolase
Homologous Superfamily 3.90.79.10 Nucleoside Triphosphate Pyrophosphohydrolase

Domain Context

CATH Clusters

Superfamily Nucleoside Triphosphate Pyrophosphohydrolase
Functional Family 8-oxo-dGTP diphosphatase MutT

Enzyme Information

3.6.1.55
8-oxo-dGTP diphosphatase.
based on mapping to UniProt P08337
8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate.
-!- This enzyme hydrolyzes the phosphoanhydride bond between the alpha and beta phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA. -!- It does not hydrolyze 2-hydroxy-dATP (cf. EC 3.6.1.56).

UniProtKB Entries (1)

P08337
MUTT_ECOLI
Escherichia coli K-12
8-oxo-dGTP diphosphatase

PDB Structure

PDB 3A6U
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base
Nakamura, T., Meshitsuka, S., Kitagawa, S., Abe, N., Yamada, J., Ishino, T., Nakano, H., Tsuzuki, T., Doi, T., Kobayashi, Y., Fujii, S., Sekiguchi, M., Yamagata, Y.
J.Biol.Chem.
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