×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

1 keywords

CATH Domain 2xvnB00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.20 Alpha-Beta Barrel
Topology 3.20.20 TIM Barrel
Homologous Superfamily 3.20.20.80 Glycosidases

Domain Context

CATH Clusters

Superfamily Glycosidases
Functional Family Class III chitinase ChiA1

Enzyme Information

3.2.1.14
Chitinase.
based on mapping to UniProt Q873Y0
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.
-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.

UniProtKB Entries (1)

Q873Y0
CHIA1_ASPFM
Aspergillus fumigatus
Endochitinase A1

PDB Structure

PDB 2XVN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Natural Product-Guided Discovery of a Fungal Chitinase Inhibitor.
Rush, C.L., Schuttelkopf, A.W., Hurtado-Guerrero, R., Blair, D.E., Ibrahim, A.F.M., Desvergnes, S., Eggleston, I.M., Van Aalten, D.M.F.
Chem.Biol.
CATH-Gene3D is a Global Biodata Core Resource Learn more...