CATH Domain 2xsnA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.800	Phenylalanine Hydroxylase
	1.10.800.10	Aromatic amino acid hydroxylase

Domain Context

CATH Clusters

Superfamily	Aromatic amino acid hydroxylase
Functional Family	Tyrosine 3-monooxygenase

Enzyme Information

1.14.16.2

Tyrosine 3-monooxygenase.

based on mapping to UniProt P07101

L-tyrosine + tetrahydrobiopterin + O(2) = L-dopa + 4a-hydroxytetrahydrobiopterin.

-!- Activated by phosphorylation, catalyzed by EC 2.7.11.27. -!- The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7- dihydrobiopterin, both spontaneously and by the action of EC 4.2.1.96. -!- The 6,7-dihydrobiopterin can be enzymically reduced back to tetrahydrobiopterin, by EC 1.5.1.34, or slowly rearranges into the more stable compound 7,8-dihydrobiopterin.

UniProtKB Entries (1)

P07101

TY3H_HUMAN

Homo sapiens

Tyrosine 3-monooxygenase

PDB Structure

PDB	2XSN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of Human Tyrosine Hydroxylase Catalytic Domain Muniz, J.R.C., Cooper, C.D.O., Yue, W.W., Krysztofinska, E., von Delft, F., Knapp, S., Gileadi, O., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Kavanagh, K.L., Oppermann, U. To be Published

Network disruptions