CATH Domain 2wweA01

Superfamily	Phox-like domain
Functional Family	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma

2.7.1.154

Phosphatidylinositol-4-phosphate 3-kinase.

based on mapping to UniProt O75747

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl- 1D-myo-inositol 3,4-bisphosphate.

-!- This enzyme also phosphorylates PtdIns to PtdIns3P.

P3C2G_HUMAN

Homo sapiens

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma

PDB	2WWE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of the Phox Homology Domain of Human Phosphoinositide-3-Kinase-C2-Gamma Roos, A.K., Tresaugues, L., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Kallas, A., Karlberg, T., Kotyenova, T., Kotzch, A., Kraulis, P., Markova, N., Moche, M., Nielsen, T.K., Nyman, T., Persson, C., Schuler, H., Schutz, P., Siponen, M.I., Svensson, L., Thorsell, A.G., Van Den Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Wisniewska, M., Nordlund, P., Structural Genomics Consortium (SGC) To be Published