CATH Domain 2wtbA02

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Fatty oxidation complex, alpha subunit

Enzyme Information

4.2.1.17	Enoyl-CoA hydratase. based on mapping to UniProt Q9ZPI5 (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O. -!- Acts in the reverse direction. -!- With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74).
1.1.1.35	3-hydroxyacyl-CoA dehydrogenase. based on mapping to UniProt Q9ZPI5 (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. -!- Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate. -!- Some enzymes act, more slowly, with NADP(+). -!- Broad specificity to acyl chain-length (cf. EC 1.1.1.211).
5.3.3.8	Delta(3)-Delta(2)-enoyl-CoA isomerase. based on mapping to UniProt Q9ZPI5 (1) A (3Z)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA. (2) A (3E)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA. -!- The enzyme participates in the beta-oxidation of fatty acids with double bonds at an odd position. -!- Processing of these substrates via the beta-oxidation system results in intermediates with a cis- or trans-double bond at position C(3), which cannot be processed further by the regular enzymes of the beta- oxidation system. -!- This enzyme isomerizes the bond to a trans bond at position C(2), which can be processed further. -!- The reaction rate is ten times higher for the (3Z) isomers than for (3E) isomers. -!- The enzyme can also catalyze the isomerization of 3-acetylenic fatty acyl thioesters to 2,3-dienoyl fatty acyl thioesters.
5.1.2.3	3-hydroxybutyryl-CoA epimerase. based on mapping to UniProt Q9ZPI5 (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA.

UniProtKB Entries (1)

MFP2_ARATH

Arabidopsis thaliana

Peroxisomal fatty acid beta-oxidation multifunctional protein MFP2

PDB Structure

PDB	2WTB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Multi-Functional Protein in Peroxisomal Beta-Oxidation. Structure and Substrate Specificity of the Arabidopsis Thaliana Protein, Mfp2 Arent, S., Pye, V.E., Christen, C.E., Norgaard, A., Henriksen, A. J.Biol.Chem.