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1 keywords

CATH Domain 2wk1A00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.150 Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Macrocin O-methyltransferase

Enzyme Information

2.1.1.285
Demethyldecarbamoylnovobiocin O-methyltransferase.
based on mapping to UniProt Q9L9F2
S-adenosyl-L-methionine + demethyldecarbamoylnovobiocin = S-adenosyl-L- homocysteine + decarbamoylnovobiocin.
-!- The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin.

UniProtKB Entries (1)

Q9L9F2
NOVP_STRNV
Streptomyces niveus
Demethyldecarbamoylnovobiocin O-methyltransferase

PDB Structure

PDB 2WK1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Crystal Structure of the Novobiocin Biosynthetic Enzyme Novp: The First Representative Structure for the Tylf O-Methyltransferase Superfamily.
Gomez Garcia, I., Stevenson, C.E.M., Uson, I., Freel Meyers, C.L., Walsh, C.T., Lawson, D.M.
J.Mol.Biol.
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