CATH Domain 2vr2A01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.140	Metal-dependent hydrolases

Domain Context

CATH Clusters

Superfamily	Metal-dependent hydrolases
Functional Family	Dihydropyrimidinase like 2

Enzyme Information

3.5.2.2

Dihydropyrimidinase.

based on mapping to UniProt Q14117

5,6-dihydrouracil + H(2)O = 3-ureidopropanoate.

-!- Also acts on dihydrothymine and hydantoin.

UniProtKB Entries (1)

DPYS_HUMAN

Homo sapiens

Dihydropyrimidinase

PDB Structure

PDB	2VR2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Crystal Structure of Human Dihydropyrimidinase Welin, M., Karlberg, T., Andersson, J., Arrowsmith, C.H., Berglund, H., Busam, R.D., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Herman, M.D., Johansson, I., Kallas, A., Kotenyova, T., Lehtio, L., Moche, M., Nilsson, M.E., Nyman, T., Persson, C., Sagemark, J., Svensson, L., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Weigelt, J., Wikstrom, M., Nordlund, P. To be Published