CATH Domain 2v0rA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.10	Deoxyribonuclease I; Chain A
	3.60.10.10	Endonuclease/exonuclease/phosphatase

Domain Context

CATH Clusters

Superfamily	Endonuclease/exonuclease/phosphatase
Functional Family

Enzyme Information

2.7.7.49	RNA-directed DNA polymerase. based on mapping to UniProt O00370 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
3.1.21.-	Endodeoxyribonucleases producing 5'-phosphomonoesters. based on mapping to UniProt O00370

UniProtKB Entries (1)

LORF2_HUMAN

Homo sapiens

LINE-1 retrotransposable element ORF2 protein

PDB Structure

PDB	2V0R
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Determinants for DNA Target Structure Selectivity of the Human Line-1 Retrotransposon Endonuclease Repanas, K., Zingler, N., Layer, L.E., Schumann, G.G., Perrakis, A., Weichenrieder, O. Nucleic Acids Res.