CATH Domain 2tmkB00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	Thymidylate kinase

Enzyme Information

2.7.4.9

dTMP kinase.

based on mapping to UniProt P00572

ATP + dTMP = ADP + dTDP.

UniProtKB Entries (1)

KTHY_YEAST

Saccharomyces cerevisiae S288C

Thymidylate kinase

PDB Structure

PDB	2TMK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation. Lavie, A., Vetter, I.R., Konrad, M., Goody, R.S., Reinstein, J., Schlichting, I. Nat.Struct.Biol.