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1 keywords

CATH Domain 2r42A01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.230 Ribosomal Protein S5; domain 2
Homologous Superfamily 3.30.230.10  

Domain Context

CATH Clusters

Superfamily 3.30.230.10
Functional Family Mevalonate kinase

Enzyme Information

2.7.1.36
Mevalonate kinase.
based on mapping to UniProt P17256
ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate.
-!- CTP, GTP and UTP can also act as donors.

UniProtKB Entries (1)

P17256
KIME_RAT
Rattus norvegicus
Mevalonate kinase

PDB Structure

PDB 2R42
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Biochemical and Structural Basis for Feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism.
Fu, Z., Voynova, N.E., Herdendorf, T.J., Miziorko, H.M., Kim, J.J.
Biochemistry
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