CATH Domain 2q8uA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.160	Double Stranded RNA Binding Domain
	3.30.160.210	DNA double-strand break repair nuclease

Domain Context

CATH Clusters

Superfamily	DNA double-strand break repair nuclease
Functional Family

Enzyme Information

UniProtKB Entries (1)

Q9X1X0_THEMA

Thermotoga maritima MSB8

Nuclease SbcCD subunit D

PDB Structure

PDB	2Q8U
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of the first eubacterial Mre11 nuclease reveals novel features that may discriminate substrates during DNA repair. Das, D., Moiani, D., Axelrod, H.L., Miller, M.D., McMullan, D., Jin, K.K., Abdubek, P., Astakhova, T., Burra, P., Carlton, D., Chiu, H.J., Clayton, T., Deller, M.C., Duan, L., Ernst, D., Feuerhelm, J., Grant, J.C., Grzechnik, A., Grzechnik, S.K., Han, G.W., Jaroszewski, L., Klock, H.E., Knuth, M.W., Kozbial, P., Krishna, S.S., Kumar, A., Marciano, D., Morse, A.T., Nigoghossian, E., Okach, L., Paulsen, J., Reyes, R., Rife, C.L., Sefcovic, N., Tien, H.J., Trame, C.B., van den Bedem, H., Weekes, D., Xu, Q., Hodgson, K.O., Wooley, J., Elsliger, M.A., Deacon, A.M., Godzik, A., Lesley, S.A., Tainer, J.A., Wilson, I.A. J.Mol.Biol.