CATH Domain 2px7B00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.550	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
	3.90.550.10	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A

Domain Context

CATH Clusters

Superfamily	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Functional Family

Enzyme Information

2.7.7.60

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase.

based on mapping to UniProt Q5SLX2

CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.

-!- ATP or UTP can replace CTP, but both are less effective. -!- GTP and TTP are not substrates. -!- Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.

UniProtKB Entries (1)

Q5SLX2

ISPD_THET8

Thermus thermophilus HB8

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

PDB Structure

PDB	2PX7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase from Thermus thermophilus HB8. Chen, L., Tsukuda, M., Ebihara, A., Shinkai, A., Kuramitsu, S., Yokoyama, S., Chen, L.-Q., Liu, Z.-J., Lee, D., Chang, S.-H., Nguyen, D., Rose, J.P., Wang, B.-C. To be Published

Network disruptions