CATH Domain 2oyzA00

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.10	Jelly Rolls

Domain Context

CATH Clusters

Superfamily	Jelly Rolls
Functional Family	Pyrimidine/purine nucleoside phosphorylase

Enzyme Information

2.4.2.3	Uridine phosphorylase. based on mapping to UniProt Q87K41 Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. -!- The enzyme participates the the pathways of pyrimidine ribonucleosides degradation and salvage. -!- The mammalian enzyme also accepts 2'-deoxyuridine. -!- Formerly EC 2.4.2.23.
2.4.2.15	Guanosine phosphorylase. based on mapping to UniProt Q87K41 Guanosine + phosphate = guanine + alpha-D-ribose 1-phosphate. -!- Also acts on deoxyguanosine.
2.4.2.2	Pyrimidine-nucleoside phosphorylase. based on mapping to UniProt Q87K41 (1) Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. (2) Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. (3) 2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate. -!- Unlike EC 2.4.2.3 and EC 2.4.2.4, this enzyme can accept both the ribonucleoside uridine and the 2'-deoxyribonucleosides 2'-deoxyuridine and thymidine. -!- The reaction is reversible, and the enzyme does not distinguish between alpha-D-ribose 1-phosphate and 2-deoxy-alpha-D-ribose 1-phosphate in the synthetic direction. -!- Formerly EC 2.4.2.23.
2.4.2.4	Thymidine phosphorylase. based on mapping to UniProt Q87K41 Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. -!- In some tissues also catalyzes deoxyribosyltransferase reactions of the type catalyzed by EC 2.4.2.6. -!- Formerly EC 2.4.2.23.

UniProtKB Entries (1)

PPNP_VIBPA

Vibrio parahaemolyticus RIMD 2210633

Pyrimidine/purine nucleoside phosphorylase

PDB Structure

PDB	2OYZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of unknown function protein VPA0057 from Vibrio parahaemolyticus Chang, C., Volkart, L., Abdullah, J., Joachimiak, A. To be Published