CATH Domain 2okjA02

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.640	Aspartate Aminotransferase; domain 2
	3.40.640.10	Type I PLP-dependent aspartate aminotransferase-like (Major domain)

Domain Context

CATH Clusters

Superfamily	Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family

Enzyme Information

4.1.1.15

Glutamate decarboxylase.

based on mapping to UniProt Q99259

L-glutamate = 4-aminobutanoate + CO(2).

-!- The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate.

UniProtKB Entries (1)

DCE1_HUMAN

Homo sapiens

Glutamate decarboxylase 1

PDB Structure

PDB	2OKJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Saccharomyces
Primary Citation	GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop. Fenalti, G., Law, R.H.P., Buckle, A.M., Langendorf, C., Tuck, K., Rosado, C.J., Faux, N.G., Mahmood, K., Hampe, C.S., Banga, J.P., Wilce, M., Schmidberger, J., Rossjohn, J., El-Kabbani, O., Pike, R.N., Smith, A.I., Mackay, I.R., Rowley, M.J., Whisstock, J.C. Nat.Struct.Mol.Biol.