CATH Domain 2o4iB01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.10	Ribonuclease H-like superfamily/Ribonuclease H

Domain Context

CATH Clusters

Superfamily	Ribonuclease H-like superfamily/Ribonuclease H
Functional Family	Three prime repair exonuclease 1

Enzyme Information

3.1.11.2

Exodeoxyribonuclease III.

based on mapping to UniProt Q91XB0

Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.

-!- Preference for double-stranded DNA. -!- Has endonucleolytic activity near apurinic sites on DNA. -!- Similar enzyme: Haemophilus influenzae exonuclease. -!- Formerly EC 3.1.4.27.

UniProtKB Entries (1)

Q91XB0

TREX1_MOUSE

Mus musculus

Three-prime repair exonuclease 1

PDB Structure

PDB	2O4I
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW Domains. Brucet, M., Querol-Audi, J., Serra, M., Ramirez-Espain, X., Bertlik, K., Ruiz, L., Lloberas, J., Macias, M.J., Fita, I., Celada, A. J.Biol.Chem.