CATH Domain 2mdiA00

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.20	Single Sheet
	2.20.70	Ubiquitin Ligase Nedd4; Chain: W;
	2.20.70.10

Domain Context

CATH Clusters

Superfamily	2.20.70.10
Functional Family

Enzyme Information

2.1.1.-	Methyltransferases. based on mapping to UniProt Q9BYW2
2.1.1.43	Histone-lysine N-methyltransferase. based on mapping to UniProt Q9BYW2 S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

SETD2_HUMAN

Homo sapiens

Histone-lysine N-methyltransferase SETD2

PDB Structure

PDB	2MDI
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	Autoinhibitory structure of the WW domain of HYPB/SETD2 regulates its interaction with the proline-rich region of huntingtin. Gao, Y.G., Yang, H., Zhao, J., Jiang, Y.J., Hu, H.Y. Structure