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1 keywords

CATH Domain 2l9uA00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.20 Up-down Bundle
Topology 1.20.890 cAMP-dependent Protein Kinase, Chain A
Homologous Superfamily 1.20.890.10 cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain

Domain Context

CATH Clusters

Superfamily cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
Functional Family

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P21860
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P21860
ERBB3_HUMAN
Homo sapiens
Receptor tyrosine-protein kinase erbB-3

PDB Structure

PDB 2L9U
External Links
Method SOLUTION NMR
Organism
Primary Citation
Spatial structure and dimer--monomer equilibrium of the ErbB3 transmembrane domain in DPC micelles.
Mineev, K.S., Khabibullina, N.F., Lyukmanova, E.N., Dolgikh, D.A., Kirpichnikov, M.P., Arseniev, A.S.
Biochim. Biophys. Acta
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