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1 keywords

CATH Domain 2k31A00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.450 Beta-Lactamase
Homologous Superfamily 3.30.450.40 GAF domain

Domain Context

CATH Clusters

Superfamily 3.30.450.40
Functional Family Phosphodiesterase

Enzyme Information

3.1.4.35
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt Q8CG03
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

UniProtKB Entries (1)

Q8CG03
PDE5A_MOUSE
Mus musculus
CGMP-specific 3',5'-cyclic phosphodiesterase

PDB Structure

PDB 2K31
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5: Insights into Nucleotide Selectivity, Dimerization, and cGMP-Dependent Conformational Change.
Heikaus, C.C., Stout, J.R., Sekharan, M.R., Eakin, C.M., Rajagopal, P., Brzovic, P.S., Beavo, J.A., Klevit, R.E.
J.Biol.Chem.
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